ACUITY MEDICAL SYSTEMS

MACULAR DEGENERATION PREDICTION CALCULATOR

(Supporting Informational Sources)

July 4, 2009

  1. Bio-Medicine, Research from Columbia University, 3/6/06; A study of 1300 people identifies Factors B & H as an underlying cause of MD in 74% of individuals.  http://www.bio-medicine.org/medicine-news/Age-Related-Macular-Degeneration-Linked-To-Two-Genes-8274-1/
  2. Medicine.Net.com “Gene Linked to ‘Dry’ Macular Degeneration”, Alan Mozes, Health Day reporter, Healthday News,  Aug, 27, 2008, Scientists from USA and China discover mutated gene TLR3 with a role in dry AMD. http://www.medicinenet.com/script/main/art.asp?articlekey=92229
  3. The Eye Digest, University of Illinois Eye & Ear Infirmary; Risk Factors Summarized; May 19, 2009; http://www.agingeye.net/maculardegen/maculardegeninformation.php
  4. The Eye Digest, University of Illinois Eye & Ear Infirmary; “Macular Degeneration Gene Discovered”,  CFH gene varient. http://www.agingeye.net/mainnews/gene.php
  5. Science Direct, Ophthalmology, Vol 108, Issue 4, pp 697-704; W. Smith; Summary of a 14,752 participant study indicating AMD prevalence correlated to age. http://linkinghub.elsevier.com/retrieve/pii/S0161642000005807
  6. Holz FG, Wolfensberger TJ, Piquet B, Gross-Jendroska, M et.al., “Bilateral Macular Drusen in age-related Macular Degeneration. Prognosis and Risk Factors”, Ophthalmology, Sept, 1994: 101(9): 1522-28. Dept. of Clinical and Preventive Ophthalmology, Moorfields Eye Hospital, London, UK.  http://www.ncbi.nih.gov/pubmed/8090455
  7. West S, PhD; Rosenthal FS, PhD; Bressler, NM; MD; Bressler SB, MD; et.al.,  “Exposure to Sunlight and Other Risk Factors for Age-Related Macular Degeneration”, Arch Ophthalmol. 1989; 107(6): 875-879.  http://archopht.highwire.org/cgi/content/abstract/107/6/875
  8. Evans, Jennifer R., “Risk Factors for Age-Related Macular Degeneration”, Science Direct, 2/9/2001; Dept. of Epidemiology and Int’l Eye Health, Inst. Of phthalmology, London, UK. http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TBT-4
  9. Hageman G; Anderson, DH; Johnson, LV; Hancox LS; et.al. Abstract, “A Common Halotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to Age-related Macular Degeneration”. 2/2/2005, The Johns Hopkins School of Medicine, Baltimore, MD. pp: 1-15. http://www.pnas.org/content/102/20/7227.abstract
  10. Rivera A, Fischer S, Fritsche L, et. al. “Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement Factor H to disease risk.” Human Molecular Genetics, Sept. 16, 2005,  http://hmg.oxfordjournals.org/cgi/content/abstract/14/21/3227
  11. Seddon JM, MD; Rosner B, PhD; Sperduto, RD, MD; et. al. “Dietary Fat and Risk for Advanced Age-Related Macular Degeneration”, Archives of Ophthalmology, Vol 119, No. 8, August 2001, pp 1191-99.  http://archopht.ama-asn.org/cgi/content/abstract/119/8/1191
  12. Clemons TE, Milton RC, Klein R, et. al. “Risk factors for the incidence of Advanced Age-Related Macular Degeneration in the Age-Related Eye Disease Study (AREDS) AREDS Report No. 19; Ophthalmology, April 2005, 112(4): pp 533-539. http://www.be-md.ncbi.nim.nih.gov/pubmed/15808240
  13. Snodderly DM, “Evidence for Protection Against Age-related Macular Degeneration by Carotenoids and Antioxidant Vitamins”, American Journal of Clinical Nutrition, Vol. 62, 1448S-1461S, Copyright 1995. http://www.ajcn.org/cgi/content/abstract/62/6/1448S
  14. Allikmets R; Shroyer NF; Singh N; et. al., “Mutation of the Stargardt Disease Gene (ABCR) in Age-related Macular Degeneration”, Science 19, Sept. 1997; Vol. 277, No. 5333 pp. 1805-07. http://www.sciencemag.org/cgi/content/abstract/277/5333/1805
  15. Beatty S; Murray IJ; Henson DB; et. al. Abstract: “Macular Pigment and Risk for Age-Related Macular Degeneration in Subjects from a Northern European Population”, Investigative Ophthalmology & Visual Science, 2001; 42:439-446.  http://www.iovs.org/cgi/content/abstrsact/42/2/439
  16. Vingerling JR; Dielemans I; Hofman A; “Macular Degeneration and early Menopause: a case-control study.”  BMJ, 1995; 310: 15570-71: June, 17. http://www.bmj.com/cgi/content/short/310/6994/1570
  17. Crabb JW, Miyagi M, Xiaorong G; et. al. “Drusen Proteome Analysis: An Approach to the Etiology of Age=Related Macular Degneration”, Harvard Medical School Paper, July 19, 2002. http://www.pnas.org/content/99/23/14682.abstract
  18. Hyman L; Lilienfield AM, Ferris, FL III; Fine, S; “Senile Macular Degeneration: A Case-Control Study”, American Journal of Epidemiology, Vol. 118, No. 2, 213-227. http://aje.oxfordjournals.org/cgi/content/abstract/118/2/213
  19. Hirvela H; Luukinen h, et. al. “Risk Factors of Age-Related Maculopathy in a Population 70 Years of Age or Older”, Ophthalmology, June 1996, 103(6): 871-877.  http://www.ncbi.nim.gov/pubmed/8643241
  20. McCarty CA PhD, MPH; Mukesh BN, PhD; el. al. “Risk Factors for Age-Related Maculopathy”, Archives of Ophthalmology, Vol 119, No. 10, October, 2001. http://archopht.ama-assn.org/cgi/content/abstract/119/10/1455
  21. Smith W, BMath, BMed; Mitchell P, FRACO; Wang JJ; “Gender Oestrogen, Hormone replacement and Age-related Macular Degeneration: results from the Blue Mountains Eye Study.” Clinical & Experimental Ophthalmology, Vol 25, issue 4, Pgs. 13-15. http://www3.interscience.wiley.com/journal/11961313/abstract?CRETRY=1&SRETRY=0
  22. Mayer, Jean; USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, “The Potential Role of Dietary Xanthophylls in Cataract and Age Related Macular Degeneration”, Journal of the American College of Nutrition, Vol 19, no. 90005; 522S-527S (2000) http://www.jacn.org/cgi/content/abstract/19/suppl_5/522S
  23. Wang JJ, MMed, PhD; Foran S, MBBS, MPH, PhD; Smith W, MBBS, MPH, PhD; “Risk of Age-Related Macular Degeneration in Eyes With Macular Drusen or Hyperpigmentation”, (The Blue Mountain Eye Study Cohort), Arch Ophthalmol 2003, 121; 658-663.  http://archopht.ama-assn/cgi/content/abstract/121/5/658
  24. Darzins P; Mitchell P; Heller RF; “Sun Exposure and Age-Related Macular Degeneration. An Australian Case-controlled Study.” Ophthalmology, May 1997, 104(5): 770-776. http://www.ncbi.nim.nih.gov/pubmed/9160021
  25. Klaver CCW, MD; Wolfs RCW; MD, MSc; Assink JA, MD; et. al. “Genetic Risk of Age Related-Maculopathy”  Archives of Ophthalmology Vol 116; no. 12, Dec. 1998,  http://archopht.ama-assn.org/cgi/content/abstract/116/12/1646
  26. Khan JC; Thurlby DA; Clayton DG Yates JRW; et. al. “Smoking and Age related macular degeneration: the number of pack years of cigarette smoking is a major determinant of risk for both geographic atrophy and choroidal neovascularisation” http://bjo.bmj.com/cgi/content/abstract/90/1/75
  27. Klein R, Klein BE, et. al. “The Wisconsin Epidemiology Study of Diabetic Retinopathy.”, Ophthalmology, 1984, Dec, 91,(12) 1464-74. http://www.ncbi.nim.nih.gov/pubmed/6521986
  28. Liu IY, White L, laCroix AZ; “The Association of Age-related Macular degeneration and lens opacities in the Aged.” American Journal of Public Health, Vol. 79, issue 6, pp. 765-769; 1989, http://www.ajph.org/cgi/content/abstract/79/6/765
  29. Krishnaiah S, Das T, et. al. “Rish Factors for Age-Related Macular Degeneration: Findings from the Andhra Pradesh Eye Disease Study in South India”. Investigative Ophthalmology & Visual Science, 2005, 46: pp4442-4449. http://www/iovs.org/cgi/content/abstract/46/12/4442
  30. Schamberg DA ScD, MPH, OD; et.al. “A prospective Study of 2 Major Age-Related Macular Degeneration Susceptibility Alleles and Interactions With Modifiable Risk factors.” Arch Ophthamol 2007, 125(1): pp 55-62.  http://archopht.ama-assn.org/cgi/content/abstract/125/1/55
  31. Smith M, Jasmer R MD; “Macular Degeneration Tied to Immune System Genes”, Ophthalmology, March 06, 2006., Medpage Today, http://www.medpagetoday.com/Surgery/Ophthalmology/2794
  32. “New Gene Associated With Age-Related Macular Degeneration” , Medical News Today,  http://www.medicalnewstoday.com/articles/124992.php